Home Mind + Body Methylfolate: 4 Surprising Benefits and How to Check Your Deficiency

Methylfolate: 4 Surprising Benefits and How to Check Your Deficiency

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By Mansal Denton, guest author

With the rise of personalized medicine, many people are taking health into their own hands. One of the most common ways of doing this is through genetic testing and specifically 23andme, which provides data on our physical and mental performance, which can be optimized with supplementation and lifestyle.

Millions have found methylfolate to be a powerful cognitive (and physical) enhancer after using genetic data to determine weaknesses. This article will not only cover what methylfolate can do for healthy adults, but how you can use specific tests to determine the best dosage and needs for your specific body.

What is Methylfolate?

Methylfolate is a supplement form of the essential nutrient called folate (vitamin B9). It is one of the essential nutrients that many people are deficient in for dietary and genetic reasons.

L-methylfolate is used for DNA synthesis (a process we all must go through all the time). It also helps with detoxification. Because we cannot synthesize our own folate, we need to consume it through food or supplementation.

Although some people believe that they can consume a folic acid supplement to get enough folate, this could not be further from the truth. [1][2].

The primary use for methylfolate is within our methylation cycles. The methylation cycle is one of the most important and millions of people have genetic variations that make them “poor methylators”. This is where a methylfolate supplement becomes useful.

How to Know if You Need Methylfolate

The great thing about personalized medicine tools (such as 23andme) is that they can provide a lot of crucial data on our body and brain, which we can use to optimize ourselves at a relatively low cost.

If you follow these step-by-step instructions, you will easily determine if you are a poor methylator and in need of supplementation or not. Of course, there are benefits of methylfolate whether you are deficient for genetic reasons or not, but this guide will provide some quantitative data on the subject:

  1. Buy 23andme genetic test (Health + Ancestry). Cost: $169 – 199
  2. Put your results into Genetic Genie methylation analysis
  3. BONUS: Go through Nutrahacker (pay $37) and get even better recommendations
  4. From your results, decide whether methylfolate is right for you

Many people end up with a homozygous MTHFR, for example. If this is the case, this is one of the many specific genetic predispositions that you found in your data, time to take action!

Methylfolate Benefits Based on Genetics

It’s important to note here that because our methylation cycle is so crucial for peak performance, having a deficiency or inability to utilize dietary folate properly can have huge consequences for cognitive health.

The greatest aspect of using methylfolate when there is a genetic reason for it, is that the effects are solving a root problem within your body, which is always better than a stimulant band-aid.

Benefits of Methylfolate for Healthy Adults

People who either do not know their genetic data or do not have poor methylation can still benefit from a methylfolate supplement. Those who suffer from low mood or mood imbalances may find a benefit of methylfolate [4].

Due to methylfolate’s role in the immune system, there are positive effects on our immune system as well. Increasing folate (through diet or supplementation) is associated with increased (and optimal) T-cell levels [7].

Side Effects of Methylfolate and Interactions

There are some risks associated with taking methylfolate as with any external supplement. For instance, methylfolate can invoke an allergic response in some individuals. There is also evidence to suggest methylfolate may interact with pharmaceutical antidepressants (specifically SSRIs)[9].


  1. //www.ncbi.nlm.nih.gov/pubmed/22240654
  2. //www.ncbi.nlm.nih.gov/pubmed/20357042/
  3. //www.reddit.com/r/Nootropics/comments/7kmeko/im_homozygous_mthfr_c677t_lifechanging_results/
  4. //www.ncbi.nlm.nih.gov/pubmed/1974941
  5. Ibid.
  6. //www.ncbi.nlm.nih.gov/pubmed/27567825
  7. //www.ncbi.nlm.nih.gov/pubmed/15322179/
  8. //www.ncbi.nlm.nih.gov/pubmed/22102928
  9. //www.ncbi.nlm.nih.gov/pubmed/21311704?dopt=Abstract
  10. //www.reddit.com/r/Nootropics/comments/7kmeko/im_homozygous_mthfr_c677t_lifechanging_results/
  11. //www.reddit.com/r/Nootropics/comments/6i1c48/my_bros_nothing_compares_to_methylfolate/


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